Skip to main content

Services

Bioprocess modeling
and simulation

Benefits

 
Culture_Icon_Duplicate_Expressive_Green_01
Run virtual experiments with bioprocess modeling

Train bioprocess models using your experimental data to simulate and predict bioreactor outcomes. Bioprocess modeling and simulation enables rapid iteration and optimization, reducing costly trail-and-error experiments.

Culture_Icon_Duplicate_Expressive_Green_01
Run large-scale DOEs for process optimization

Use our custom bioreactors and expert team to conduct massive Design of Experiments (DOEs) for data-driven bioprocess optimization. Our approach supports multi-factor screening, robust testing, and other advanced experimental designs critical for scaling bioprocess digital twins.

 
Culture_Icon_Duplicate_Expressive_Green_01
Gain actionable insights with data science

Securely collaborate with our team to refine your bioprocess models and enhance predictive accuracy. We support data selection, model refinement, validation, and evaluation to ensure your bioprocess digital twin accurately represents real-world conditions for improved decision-making.

Capabilities

 
Culture_Icon_Check_Expressive_Green_01
Advanced model generation for bioprocess simulation

Combine your in-house data with experimental results generated by our team at Culture Biosciences to build robust bioprocess models. We support mechanistic modeling, hybrid approaches, predictive run-stopping models, and more, helping you confidently simulate and optimize processes.

Culture_Icon_Check_Expressive_Green_01
Head-to-head DOE comparison

Evaluate trade-offs between different Design of Experiments (DOE) strategies, including factor sensitivity and study fragility. Our modeling approach identifies optimal conditions for your experiments, reducing variability and improving process scale-up.

 
Culture_Icon_Check_Expressive_Green_01
Data science-driven virtual experiments

Use our high-performance bioprocess simulation tools to assess thousands of bioreactor conditions by integrating real experimental data with advanced computational models. Our bioprocess digital twin technology accelerates process development, enabling rapid, data-driven decision-making.

Our facility

Our laboratories based in San Francisco are equipped with segregated modality suites, state-of-the-art bioreactors and analytical instrumentation, all operated by an experienced bioprocess development team.

facility-1
facility-2
facility-3

350+

250mL and 5L bioreactors

20,000+

Bioreactor runs to date

70+

Customers have used Culture's services to date

High quality & safety standards

Analytical capabilities
  • Microbial bioprocess
    - Biomass quantification
    - Metabolite analysis
  • Mammalian bioprocess
    - Viability and cell counts
    - Metabolite analysis - Host cell protein
  • Protein
    - Titer quantification
    - Monomer/aggregation quantification
  • Viral vector
    - Capsid titer
    - Viral genome titer
    - Empty/full ratio
Segregated modality suites
  • Mammalian
    CHO and HEK
  • Viral vector (AAV)
    AAV generated by HEK transfection
  • Microbial
    Yeast, bacteria, and fungi
  • Media
    Media recipes to customer specifications
Rigorous standards
  • Quality management systems (QMS)
    Quality review of all runs and CAPA for major deviations
  • Safety & security
    BSL-2 and SOC2 compliant

Our bioreactors

At Culture, we custom-build our reactors to be cloud-connected and modular, making bioprocess scale-out, design, monitoring, and analysis as easy as possible.

250mL bench-scale single-use bioreactor

Benchtop bioreactor for process development

5L single-use bioreactor

Our modular bioreactors are designed to be easily scaled up or down.

Explore our other service packages

Clone, strain & construct screening

Clone, strain & construct screening in our bioreactors

Process development

Upstream process development and optimization

Process characterization

Accelerate process characterization development and cell culture optimization with scalable, data-driven experimentation.

Bioreactor scale-out

Leverage bioreactor capacity when you need it

Optimize your bioprocess with Culture