Services

Process characterization

Accelerate process characterization development and cell culture optimization with scalable, data-driven experimentation.

Use our advanced bioreactors and Design of Experiments (DoE) expertise to perform cell culture process characterization prior to PPQ. Assess your upstream process in scale-down bioreactors that allow for enhanced model curvature, deeper variable exploration, and more robust process characterization development.

Benefits

Debottleneck cell culture process characterization

Leverage a high-throughput platform built for process characterization. Our large fleet of custom bioreactors and experienced team help you run extensive DoE studies to define Critical Process Parameters (CPPs) efficiently and cost-effectively.

Avoid large, upfront CAPEX and FTE training

Outsource your process characterization development to Culture’s team instead of investing in lab build-outs, capital equipment, and staff training. Our infrastructure allows you to focus resources on decision-making, not setup.

Transparent, real-time cell culture optimization data

Access real-time insights with our cloud-connected bioreactors. Live monitoring of your cell culture process characterization runs allows for faster iteration, better decision-making, and more confident downstream transfer. Gain full visibility into experimental performance at every stage.

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Capabilities

Run extensive DOEs

We support high-volume DoE execution for cell culture optimization and process characterization development, including multi-factor screening, interaction modeling, and late-stage refinement.

DOE design and data analysis support

Our data science team brings deep expertise in statistical modeling, power analysis, and outcome interpretation. Let us help design your process characterization studies and extract actionable insights.

Cloud-connected, real-time monitoring

Track every run in real time via our cloud-based platform. Monitor variables, trends, and performance metrics instantly during cell culture process characterization, gaining unparalleled control over your upstream experimentation.

Having access to Culture’s Cloud Lab has allowed us to pursue multiple projects simultaneously.

Darcy Prather

Co-founder and President

Kalion

Our facility

Our laboratories based in San Francisco are equipped with segregated modality suites, state-of-the-art bioreactors and analytical instrumentation, all operated by an experienced bioprocess development team.

group of scientists with Bioreactors - Culture Bio

350+

250mL and 5L bioreactors

20,000+

Bioreactor runs to date

70+

Customers have used Culture's services to date

High quality & safety standards

Analytical capabilities

Microbial bioprocess

- Biomass quantification
- Metabolite analysis

Mammalian bioprocess

- Viability and cell counts 
- Metabolite analysis
- Host cell protein

Protein

- Titer quantification
- Monomer/aggregation quantification

Viral vector

- Capsid titer
- Viral genome titer
- Empty/full ratio

Segregated modality suites

Mammalian

CHO and HEK

Viral vector (AAV)

AAV generated by HEK transfection

Microbial

Yeast, bacteria, and fungi

Media

Media recipes to customer specifications

Rigorous standards

Quality management systems (QMS)

Quality review of all runs and CAPA for major deviations

Safety & security

BSL-2 and SOC2 compliant

Our bioreactors

At Culture, we custom-build our modular reactors with cloud-connected controllers, making bioprocess scale-out, design, monitoring, and analysis as easy as possible.