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Services

Process development

Benefits

 
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Cell culture media optimization and development

Cell culture media optimization and development is critical to achieving efficient and reproducible outcomes in upstream bioprocessing. Our cutting-edge technology and deep expertise is combined to help you maximize productivity and ensure consistent performance at scale.

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Accelerated media development

Using our DOE methodology, we accelerate the development process by testing multiple variables simultaneously. This approach provides data-driven insights to help shorten development timelines, reduce variability across experiments, and scale formulations from lab to production environments.

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Support across various systems

Finally, we support cell culture media optimization and development across various systems, including CHO Cells, HEK Cells, and Yeast and Microbial Systems.

 
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Customized media optimization

We work with you to design, test, and refine media formulations tailored to your cell lines and production goals. Using our cloud-connected bioreactors, we can evaluate nutrient profiles to enhance growth and protect yields, test feed strategies to maintain cell health in high-density cultures, and identify and optimize critical media components to improve performance.

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Real-time monitoring

Cloud-connected bioreactors enable real-time monitoring of cell culture experiments for hastened optimization of critical process parameters. The power and outcome analysis ensure media is optimized for consistent and high-performing results.

Capabilities

 
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Cloud-connected bioreactors

Real-time monitoring, data collection, and precise control improve experimental outcomes and scalability.

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Analysis and insights

Advanced monitoring tools for power and experimental outcome analysis enable assessment of critical process parameters - such as growth rates, metabolite profiles, and protein yields - to promote data-driven decision-making.

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Design of experiments (DOE)

Our fleet of bioreactors is configurable to run multi-factor DOEs of nearly any size, applying systematic and data-driven experimental design to optimize bioprocess parameters efficiently and reduce variability across experiments.

 
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High-throughput experimentation

Simultaneously test multiple variables to refine processes faster and more efficiently.

 
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Cell culture optimization and development

Tailored support for formulating, testing, and scaling cell culture media to maximize productivity and reproducibility.

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Expert collaboration

Access a team of experienced bioprocess scientists to design, execute, and refine experiments for optimal outcomes.

Having access to Culture’s Cloud Lab has allowed us to pursue multiple projects simultaneously.

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Darcy Prather

Co-founder and President, Kalion

Our facility

Our laboratories based in San Francisco are equipped with segregated modality suites, state-of-the-art bioreactors and analytical instrumentation, all operated by an experienced bioprocess development team.

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350+

250mL and 5L bioreactors

20,000+

Bioreactor runs to date

70+

Customers have used Culture's services to date

High quality & safety standards

Analytical capabilities
  • Microbial bioprocess
    - Biomass quantification
    - Metabolite analysis
  • Mammalian bioprocess
    - Viability and cell counts
    - Metabolite analysis - Host cell protein
  • Protein
    - Titer quantification
    - Monomer/aggregation quantification
  • Viral vector
    - Capsid titer
    - Viral genome titer
    - Empty/full ratio
Segregated modality suites
  • Mammalian
    CHO and HEK
  • Viral vector (AAV)
    AAV generated by HEK transfection
  • Microbial
    Yeast, bacteria, and fungi
  • Media
    Media recipes to customer specifications
Rigorous standards
  • Quality management systems (QMS)
    Quality review of all runs and CAPA for major deviations
  • Safety & security
    BSL-2 and SOC2 compliant

Our bioreactors

At Culture, we custom-build our reactors to be cloud-connected and modular, making bioprocess scale-out, design, monitoring, and analysis as easy as possible.

250mL bench-scale single-use bioreactor

Benchtop bioreactor for process development

5L single-use bioreactor

Our modular bioreactors are designed to be easily scaled up or down.

Explore our other service packages

Clone, strain & construct screening

Clone, strain & construct screening in our bioreactors

Process characterization

Accelerate process characterization development and cell culture optimization with scalable, data-driven experimentation.

Bioprocess modeling and simulation

Create bioprocess digital twins for scalable biomanufacturing in collaboration with our data science team

Bioreactor scale-out

Leverage bioreactor capacity when you need it

Optimize your bioprocess with Culture