Applications

Viral vectors

Accelerate and de-risk your viral vector upstream development with Culture

Culture accelerates and de-risks upstream process development for viral vectors by parallelizing experiments to reduce program bottlenecks.

Bioreactor with media - Culture Bioscience

Benefits

Increase speed to clinic and manufacturing milestones

Save 6-18 months in your protein therapeutic development timeline with access to our cloud-connected bioreactor facility. Instead of dedicating time and resources to building your own lab infrastructure, focus on advancing your protein therapeutic pipeline. Our streamlined workflows and advanced systems are purpose-built to accelerate key milestones in clinic and manufacturing, helping you bring innovative therapies to market faster.

Scale fermentation without infrastructure delays

Skip the time and cost of lab build-outs. Our cloud-connected bioreactors (250mL and 5L) provide on-demand fermentation capacity, while Stratyx250 enables in-house process testing for early-stage development.

Run massive DOEs to optimize viral genome titer, capsid titer, or other process residuals

Our team and innovative cloud-connected bioreactors support large DOEs for process optimization. Evaluate process optimizations including plasmid ratios, viable cell density at transfection, agitation, pH, and other bioreactor specific parameters.

Capabilities

Unleash your construct screening

Use our bioreactors to evaluate your viral vector constructs to get to your most desired outcome. Scaling-out your construct screening will save time and get you to your best outcome faster.

Parallelize upstream and downstream development with material generation

Generate material for downstream, drug product, and analytical activities. Outsource routine material supply to supplement your upstream capacity.

In-house viral vector analytics for faster process development

Analyze your vector product attributes with ddPCR, capsid ELISA, HCP, and HCDNA. Monitor your process with VCD, pH, and metabolites.

Service packages

Whether you want to work with Culture on a continuous or per project basis, we have a service package tailored to your specific goals.

Clone, strain & construct screening

Evaluate your bio clones, strains, and viral constructs with scalable flexibility using our advanced cell culture bioreactors. Our platform ensures efficient clone screening systems for optimal performance.

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Process development

Accelerate timelines, optimize performance, and reduce risks in bringing biotherapeutics to market with our upstream process development services and advanced bioreactor technology. By focusing on cell culture media optimization and development, we can help ensure your experiments deliver efficient and reproducible outcomes.

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Process characterization

Use our advanced bioreactors and Design of Experiments (DoE) expertise to perform cell culture process characterization prior to PPQ. Assess your upstream process in scale-down bioreactors that allow for enhanced model curvature, deeper variable exploration, and more robust process characterization development.

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Bioprocess modeling and simulation

Scaling a bioprocess from R&D to manufacturing is challenging. Bioprocess modeling and simulation enables precise control over process conditions, improving efficiency and reducing variability. Our services offer a bioprocess digital twin approach to streamline development, leveraging advanced modeling to simulate and optimize conditions before running costly experiments.

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Bioreactor scale-out

Run multiple experiments using our parallel bioreactor systems, which are cloud-connected 250mL and 5L bioreactors managed in our facility for high-throughput optimization to ensure process consistency, accelerated development, and seamless scalability. For those seeking an in-house solution, Stratyx250 provides a disposable 250mL bioreactor that users can implement directly in their own labs for greater control. While you will be limited on the number of experiments you can run on your own, you can pair our Stratyx platform running in your lab with the bioreactors running in ours.

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