Services

Bioprocess modeling and simulation

Create bioprocess digital twins for scalable biomanufacturing in collaboration with our data science team

Scaling a bioprocess from R&D to manufacturing is challenging. Bioprocess modeling and simulation enables precise control over process conditions, improving efficiency and reducing variability. Our services offer a bioprocess digital twin approach to streamline development, leveraging advanced modeling to simulate and optimize conditions before running costly experiments.

Benefits

Run virtual experiments with bioprocess modeling

Train bioprocess models using your experimental data to simulate and predict bioreactor outcomes. Bioprocess modeling and simulation enables rapid iteration and optimization, reducing costly trail-and-error experiments.

Gain actionable insights with data science

Securely collaborate with our team to refine your bioprocess models and enhance predictive accuracy. We support data selection, model refinement, validation, and evaluation to ensure your bioprocess digital twin accurately represents real-world conditions for improved decision-making.

Run large-scale DOEs for process optimization

Use our custom bioreactors and expert team to conduct massive Design of Experiments (DOEs) for data-driven bioprocess optimization. Our approach supports multi-factor screening, robust testing, and other advanced experimental designs critical for scaling bioprocess digital twins.

Capabilities

Advanced model generation for bioprocess simulation

Combine your in-house data with experimental results generated by our team at Culture Biosciences to build robust bioprocess models. We support mechanistic modeling, hybrid approaches, predictive run-stopping models, and more, helping you confidently simulate and optimize processes.

Data science-driven virtual experiments

Use our high-performance bioprocess simulation tools to assess thousands of bioreactor conditions by integrating real experimental data with advanced computational models. Our bioprocess digital twin technology accelerates process development, enabling rapid, data-driven decision-making.

Head-to-head DOE comparison

Evaluate trade-offs between different Design of Experiments (DOE) strategies, including factor sensitivity and study fragility. Our modeling approach identifies optimal conditions for your experiments, reducing variability and improving process scale-up.

Our facility

Our laboratories based in San Francisco are equipped with segregated modality suites, state-of-the-art bioreactors and analytical instrumentation, all operated by an experienced bioprocess development team.

group of scientists with Bioreactors - Culture Bio

350+

250mL and 5L bioreactors

20,000+

Bioreactor runs to date

70+

Customers have used Culture's services to date

High quality & safety standards

Analytical capabilities

Microbial bioprocess

- Biomass quantification
- Metabolite analysis

Mammalian bioprocess

- Viability and cell counts 
- Metabolite analysis
- Host cell protein

Protein

- Titer quantification
- Monomer/aggregation quantification

Viral vector

- Capsid titer
- Viral genome titer
- Empty/full ratio

Segregated modality suites

Mammalian

CHO and HEK

Viral vector (AAV)

AAV generated by HEK transfection

Microbial

Yeast, bacteria, and fungi

Media

Media recipes to customer specifications

Rigorous standards

Quality management systems (QMS)

Quality review of all runs and CAPA for major deviations

Safety & security

BSL-2 and SOC2 compliant

Our bioreactors

At Culture, we custom-build our modular reactors with cloud-connected controllers, making bioprocess scale-out, design, monitoring, and analysis as easy as possible.