Services

Bioreactor scale-out

Leverage bioreactor capacity when you need it

Run multiple experiments using our parallel bioreactor systems, which are cloud-connected 250mL and 5L bioreactors managed in our facility for high-throughput optimization to ensure process consistency, accelerated development, and seamless scalability. For those seeking an in-house solution, Stratyx250 provides a disposable 250mL bioreactor that users can implement directly in their own labs for greater control. While you will be limited on the number of experiments you can run on your own, you can pair our Stratyx platform running in your lab with the bioreactors running in ours.

Benefits

Accelerate process development

Run parallel bioreactor systems to conduct scale-out fermentation and cell culture scale-out experiments simultaneously, reducing bottlenecks and advancing studies faster.

Stay agile in your capacity planning

Scale your bioprocessing workload up or down based on demand. With bioreactor scale-out at Culture, you can quickly expand capacity without the constraints of biomanufacturing scale-up timelines.

Eliminate capital equipment costs

Avoid the high costs of building lab space, purchasing equipment, and hiring specialized staff by leveraging our cloud-connected bioreactors for bioprocessing scalability without infrastructure investments.

Capabilities

Overflow capacity

Remove bottlenecks in your internal bioreactors by leveraging our parallel bioreactor systems for fermentation and rapid overflow experimental capacity

Delegation of experimental processes

Offload project work like clone screening, process characterization, and process development to our team of experts. Our bioprocessing scalability platform enables you to optimize conditions efficiently before full biomanufacturing scale-out.

Material generation

Generate material for downstream processing, drug product development, and analytical activities. Our bioreactor scale-out solutions allow you to outsource routine material supply, supplementing your upstream bioreactor capacity without additional infrastructure.

Culture has been a great resource for when we have a surge in demand for bioreactor capacity.

Stefan De Kok, PhD

Director of Fermentation

Zymergen

Our facility

Our laboratories based in San Francisco are equipped with segregated modality suites, state-of-the-art bioreactors and analytical instrumentation, all operated by an experienced bioprocess development team.

group of scientists with Bioreactors - Culture Bio

350+

250mL and 5L bioreactors

20,000+

Bioreactor runs to date

70+

Customers have used Culture's services to date

High quality & safety standards

Analytical capabilities

Microbial bioprocess

- Biomass quantification
- Metabolite analysis

Mammalian bioprocess

- Viability and cell counts 
- Metabolite analysis
- Host cell protein

Protein

- Titer quantification
- Monomer/aggregation quantification

Viral vector

- Capsid titer
- Viral genome titer
- Empty/full ratio

Segregated modality suites

Mammalian

CHO and HEK

Viral vector (AAV)

AAV generated by HEK transfection

Microbial

Yeast, bacteria, and fungi

Media

Media recipes to customer specifications

Rigorous standards

Quality management systems (QMS)

Quality review of all runs and CAPA for major deviations

Safety & security

BSL-2 and SOC2 compliant

Our bioreactors

At Culture, we custom-build our modular reactors with cloud-connected controllers, making bioprocess scale-out, design, monitoring, and analysis as easy as possible.