Microbial fermentation moves fast. Substrate depletion, oxygen demand, metabolic shifts, and feed responses can happen between routine samples, leaving critical changes invisible until it’s too late.
By combining high-throughput experimentation with mass tracking, off-gas analysis, and high-resolution process data, Nexxys delivers deeper insight into fermentation performance beyond conventional sampling alone.
With Console™, teams can remotely monitor experiments and data in real time, enabling faster decisions, smarter strain and feed optimization, stronger process control, and more confident scale-up—without expanding lab footprint.
Two Culture Biosciences studies demonstrate how these integrated measurements turn every run into more actionable insight.
Better process decisions start with better mass tracking.
Culture’s mass-balance approach captures feeds, gas delivery, sampling, evaporation, and manual additions to provide real-time reactor mass estimates and more accurate yield and productivity calculations.
Across 500+ runs, more than 75% achieved 97–103% mass-balance closure, giving microbial teams greater confidence that run-to-run differences reflect biology, not measurement variability.
[Read the white paper: Data Quality & Mass Balance Calculations]
Offline samples capture moments. Continuous off-gas analysis reveals the full metabolic picture.
Nexxys continuously measures O₂ and CO₂ across high-throughput fermentations, enabling real-time tracking of oxygen uptake rate (OUR), carbon dioxide evolution rate (CER), and respiratory quotient (RQ). Performance with E. coli and S. cerevisiae showed strong agreement with a commercial analyzer.
The result, earlier insight into shifts in growth and metabolism, enabling smarter feed optimization, tighter process control, and more confident scale-up.
[Read the white paper: Custom-Built Off-Gas Analyzers for High-Throughput Fermentation]
Nexxys extends your lab while keeping you connected to every run.
Through Console™, Culture’s cloud-based bioprocess platform, teams can remotely monitor experiments, track reactor performance, and access Nexxys data in real time, from anywhere.
Nexxys runs the experiments. Console keeps you connected. Together, they give your team greater visibility to make faster, more informed decisions.
Mass balance tracks what enters, leaves, and remains in the bioreactor. Off-gas analysis reveals how cells consume oxygen and produce carbon dioxide. Console brings it all together in real time.
The result is a richer view of microbial performance across strain screens, process-development studies, and DoE campaigns, without adding equipment, infrastructure, or lab space.
Nexxys combines high-throughput fermentation, integrated process analytics, cloud-based monitoring, and bioprocess expertise to help teams understand not just what happened, but why.
Run more. Learn more. Move faster.
That’s Nexxys. Speak to one our Bioprocess Experts.