--- title: "See More in Every Fermentation: Better Data for Faster Microbial Process Development" description: Optimize microbial fermentation with Nexxys’ integrated analytics and real-time monitoring for faster, data-driven decisions in bioprocess development. image: https://www.culturebiosciences.com/hubfs/WhitePaper-Blog%20FI-Blue%20(1).png --- [Skip to main content](https://www.culturebiosciences.com/resources/see-more-in-every-fermentation-better-data-for-faster-microbial-process-development#main-content) [![Culture Biosciences](https://www.culturebiosciences.com/hubfs/2026_Culture%20Biosciences/Logos/Culture%20Logo%20black.svg) ![Culture Biosciences](https://www.culturebiosciences.com/hubfs/2026_Culture%20Biosciences/Logos/Culture%20Logo%20white.svg) ![Culture Biosciences](https://www.culturebiosciences.com/hubfs/2026_Culture%20Biosciences/Logos/Culture%20Logo%20black.svg)](https://www.culturebiosciences.com) - Show submenu for Products Products - [Console Software](https://www.culturebiosciences.com/-console) - [Stratyx Bioreactor](https://www.culturebiosciences.com/stratyx) - [Services](https://www.culturebiosciences.com/nexxys) - Show submenu for Resources Resources - [White Papers](https://www.culturebiosciences.com/resources/tag/white-paper) - [Technical Bulletins](https://www.culturebiosciences.com/resources/tag/technical-bulletin) - [Case Studies](https://www.culturebiosciences.com/resources/tag/case-study) - [Blog Posts](https://www.culturebiosciences.com/resources/tag/blog-post) - [Posters](https://www.culturebiosciences.com/resources/tag/poster) - [Announcements](https://www.culturebiosciences.com/resources/tag/announcement) - [Webinars](https://www.culturebiosciences.com/resources/tag/webinar) - [Videos](https://www.culturebiosciences.com/resources/tag/video) - [View All](https://www.culturebiosciences.com/resources) - [About](https://www.culturebiosciences.com/about) Open main navigation Close main navigation - Show submenu for Products Products - Products - [Console Software](https://www.culturebiosciences.com/-console) - [Stratyx Bioreactor](https://www.culturebiosciences.com/stratyx) - [Services](https://www.culturebiosciences.com/nexxys) - Show submenu for Resources Resources - Resources - [White Papers](https://www.culturebiosciences.com/resources/tag/white-paper) - [Technical Bulletins](https://www.culturebiosciences.com/resources/tag/technical-bulletin) - [Case Studies](https://www.culturebiosciences.com/resources/tag/case-study) - [Blog Posts](https://www.culturebiosciences.com/resources/tag/blog-post) - [Posters](https://www.culturebiosciences.com/resources/tag/poster) - [Announcements](https://www.culturebiosciences.com/resources/tag/announcement) - [Webinars](https://www.culturebiosciences.com/resources/tag/webinar) - [Videos](https://www.culturebiosciences.com/resources/tag/video) - [View All](https://www.culturebiosciences.com/resources) - [About](https://www.culturebiosciences.com/about) - [Login](https://console.culturebiosciences.com/login) [Contact](https://www.culturebiosciences.com/contact) [Login](https://console.culturebiosciences.com/login) [Contact](https://www.culturebiosciences.com/contact) Blog Post August 11, 2026 # See More in Every Fermentation: Better Data for Faster Microbial Process Development ![See More in Every Fermentation: Better Data for Faster Microbial Process Development](https://www.culturebiosciences.com/hs-fs/hubfs/WhitePaper-Blog%20FI-Blue%20(1).png?width=860&height=745&name=WhitePaper-Blog%20FI-Blue%20(1).png) Microbial fermentation moves fast. Substrate depletion, oxygen demand, metabolic shifts, and feed responses can happen between routine samples, leaving critical changes invisible until it’s too late. #### **More Than More Runs. More Insight From Every Run.** ##### **Nexxys™ Services helps microbial teams see more in every bioreactor.** By combining high-throughput experimentation with mass tracking, off-gas analysis, and high-resolution process data, [Nexxys](https://www.culturebiosciences.com/nexxys) delivers deeper insight into fermentation performance beyond conventional sampling alone. With Console™, teams can remotely monitor experiments and data in real time, enabling faster decisions, smarter strain and feed optimization, stronger process control, and more confident scale-up—without expanding lab footprint. Two Culture Biosciences studies demonstrate how these integrated measurements turn every run into more actionable insight. **Better process decisions start with better mass tracking.** Culture’s mass-balance approach captures feeds, gas delivery, sampling, evaporation, and manual additions to provide real-time reactor mass estimates and more accurate yield and productivity calculations. Across 500+ runs, more than 75% achieved 97–103% mass-balance closure, giving microbial teams greater confidence that run-to-run differences reflect biology, not measurement variability. [\[Read the white paper: Data Quality & Mass Balance Calculations\]](https://www.culturebiosciences.com/hubfs/Website%202026/PDFs/Ensuring%20Data%20Quality%20Through%20Mass%20Balance%20Calculations.pdf) #### **See Metabolic Changes in Real Time** Offline samples capture moments. Continuous off-gas analysis reveals the full metabolic picture. Nexxys continuously measures O₂ and CO₂ across high-throughput fermentations, enabling real-time tracking of oxygen uptake rate (OUR), carbon dioxide evolution rate (CER), and respiratory quotient (RQ). Performance with *E. coli* and *S. cerevisiae* showed strong agreement with a commercial analyzer. The result, earlier insight into shifts in growth and metabolism, enabling smarter feed optimization, tighter process control, and more confident scale-up. [\[Read the white paper: Custom-Built Off-Gas Analyzers for High-Throughput Fermentation\]](https://www.culturebiosciences.com/hubfs/Website%202026/PDFs/Robust%2c%20Accurate%20Off-Gas%20Analyzers%20Designed%20for%20use%20in%20Culture%20Biosciences%20high-throughput%20bioreactor%20facility.pdf) #### **Your Experiments. Your Data. Anywhere.** Nexxys extends your lab while keeping you connected to every run. Through Console™, Culture’s cloud-based bioprocess platform, teams can remotely monitor experiments, track reactor performance, and access Nexxys data in real time, from anywhere. Nexxys runs the experiments. Console keeps you connected. Together, they give your team greater visibility to make faster, more informed decisions. ## **See More of Your Process** Mass balance tracks what enters, leaves, and remains in the bioreactor. Off-gas analysis reveals how cells consume oxygen and produce carbon dioxide. Console brings it all together in real time. The result is a richer view of microbial performance across strain screens, process-development studies, and DoE campaigns, without adding equipment, infrastructure, or lab space. ## **Better Data. Faster Decisions.** Nexxys combines high-throughput fermentation, integrated process analytics, cloud-based monitoring, and bioprocess expertise to help teams understand not just *what* happened, but *why*. Run more. Learn more. Move faster. **That’s Nexxys. Speak to one our Bioprocess Experts.**  **[![Speak to Bioprocess Expert](https://hubspot-no-cache-na2-prod.s3.amazonaws.com/cta/default/43668798/interactive-208841600028.png)](https://www.culturebiosciences.com/hs/cta/wi/redirect?encryptedPayload=AVxigLKwjEbi9TiEED1wxhZlq7O%2Fwb%2FPMuCTit2fW1d8zGllPVKDPxtOFrdMjCMroypwq8IvPewGZZlWqHF%2FdjkYbaAKHf1s5eXVVp%2BeEFR2JUTwcAeslj1FizdFN4od16U1F%2F5TaN3m60AW55eE7ifPh9t53bvEj30I0ALcmz87sg80XkRcCCZ3efUPqe6E0VspcVt1FaWZ8ileehy2THJbj7VO%2BKsx%2BRyutx1tbHg%3D&webInteractiveContentId=208841600028&portalId=43668798)**   ## Complete the form to download the full PDF ## Keep exploring [See all](https://www.culturebiosciences.com/resources) [![Accelerate Bioprocess Development with Console Software](https://www.culturebiosciences.com/hs-fs/hubfs/Console-WP-LInkedIn-post.png?width=500&height=500&name=Console-WP-LInkedIn-post.png) Blog Post Accelerate Bioprocess Development with Console Software August 31, 2026](https://www.culturebiosciences.com/resources/accelerate-bioprocess-development-with-culture-console-software) [![Faster to First Data. Better to Final Results.](https://www.culturebiosciences.com/hs-fs/hubfs/Stratyx-Time%20Savings-HS=Blog-Tile%20(1).png?width=500&height=500&name=Stratyx-Time%20Savings-HS=Blog-Tile%20(1).png) Blog Post Faster to First Data. Better to Final Results. August 3, 2026](https://www.culturebiosciences.com/resources/faster-to-first-data.-better-to-final-results) [![Scaling Process Development Without Scaling Infrastructure: A Case Study](https://www.culturebiosciences.com/hs-fs/hubfs/2026_Culture%20Biosciences/Backgrounds/CultureBiosciences_About_Hero_01a.png?width=500&height=500&name=CultureBiosciences_About_Hero_01a.png) Blog Post Scaling Process Development Without Scaling Infrastructure: A Case Study July 13, 2026](https://www.culturebiosciences.com/resources/scaling-process-development-without-scaling-infrastructure-a-case-study) [![From Scale-Down Models to Real-Time Optimization: How Culture Biosciences Is Shaping the Future of Biologics Development](https://www.culturebiosciences.com/hs-fs/hubfs/LeadershipBlogV2.png?width=500&height=500&name=LeadershipBlogV2.png) Blog Post From Scale-Down Models to Real-Time Optimization: How Culture Biosciences Is Shaping the Future of Biologics Development June 22, 2026](https://www.culturebiosciences.com/resources/real-time-closed-loop-optimization-delivers-43-titer-improvement-clone) ![Culture Logo black](https://www.culturebiosciences.com/hubfs/2026_Culture%20Biosciences/Logos/Culture%20Logo%20black.svg) ### Sign up for our newsletter and grow your insights with Culture. 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