--- title: Full Factorial DOEs for Multiple CHOZN® Cell Lines description: When MilliporeSigma started optimizing media across several CHOZN® cell lines, they turned to Culture Biosciences. image: https://www.culturebiosciences.com/hubfs/Imported_Blog_Media/65f97f9af1302d315ef9aac8_Screenshot%202024-03-19%20at%201_05_33%20PM.png --- [Skip to main content](https://www.culturebiosciences.com/resources/full-factorial-does-for-multiple-chozn-r-cell-lines#main-content) [![Culture Biosciences](https://www.culturebiosciences.com/hubfs/2026_Culture%20Biosciences/Logos/Culture%20Logo%20black.svg) ![Culture Biosciences](https://www.culturebiosciences.com/hubfs/2026_Culture%20Biosciences/Logos/Culture%20Logo%20white.svg) ![Culture Biosciences](https://www.culturebiosciences.com/hubfs/2026_Culture%20Biosciences/Logos/Culture%20Logo%20black.svg)](https://www.culturebiosciences.com) - Show submenu for Products Products - [Console Software](https://www.culturebiosciences.com/console) - [Stratyx Bioreactor](https://www.culturebiosciences.com/stratyx) - [Services](https://www.culturebiosciences.com/nexxys) - Show submenu for Resources Resources - [White Papers](https://www.culturebiosciences.com/resources/tag/white-paper) - [Technical Bulletins](https://www.culturebiosciences.com/resources/tag/technical-bulletin) - [Case Studies](https://www.culturebiosciences.com/resources/tag/case-study) - [Blog Posts](https://www.culturebiosciences.com/resources/tag/blog-post) - [Posters](https://www.culturebiosciences.com/resources/tag/poster) - [Announcements](https://www.culturebiosciences.com/resources/tag/announcement) - [Webinars](https://www.culturebiosciences.com/resources/tag/webinar) - [Videos](https://www.culturebiosciences.com/resources/tag/video) - [View All](https://www.culturebiosciences.com/resources) - [About](https://www.culturebiosciences.com/about) Open main navigation Close main navigation - Show submenu for Products Products - Products - [Console Software](https://www.culturebiosciences.com/console) - [Stratyx Bioreactor](https://www.culturebiosciences.com/stratyx) - [Services](https://www.culturebiosciences.com/nexxys) - Show submenu for Resources Resources - Resources - [White Papers](https://www.culturebiosciences.com/resources/tag/white-paper) - [Technical Bulletins](https://www.culturebiosciences.com/resources/tag/technical-bulletin) - [Case Studies](https://www.culturebiosciences.com/resources/tag/case-study) - [Blog Posts](https://www.culturebiosciences.com/resources/tag/blog-post) - [Posters](https://www.culturebiosciences.com/resources/tag/poster) - [Announcements](https://www.culturebiosciences.com/resources/tag/announcement) - [Webinars](https://www.culturebiosciences.com/resources/tag/webinar) - [Videos](https://www.culturebiosciences.com/resources/tag/video) - [View All](https://www.culturebiosciences.com/resources) - [About](https://www.culturebiosciences.com/about) - [Login](https://console.culturebiosciences.com/login) [Contact](https://www.culturebiosciences.com/contact) [Login](https://console.culturebiosciences.com/login) [Contact](https://www.culturebiosciences.com/contact) White Paper December 3, 2024 # Full Factorial DOEs for Multiple CHOZN® Cell Lines ![Full Factorial DOEs for Multiple CHOZN® Cell Lines](https://www.culturebiosciences.com/hs-fs/hubfs/Imported_Blog_Media/65f97f9af1302d315ef9aac8_Screenshot%202024-03-19%20at%201_05_33%20PM.png?width=860&height=745&name=65f97f9af1302d315ef9aac8_Screenshot%202024-03-19%20at%201_05_33%20PM.png) Optimized media is a key success factor for high yield production processes. When MilliporeSigma started optimizing media across several CHOZN® cell lines, they turned to Culture Biosciences’ services with on-demand cloud-connected bioreactors. Download this white paper to learn how MilliporeSigma was able to extend in-house capacity with Nexxys by: - Supplementing internal bioreactor capacity with Nexxys’ high-throughput, cloud-connected reactors. - Running large-scale Design of Experiments (DOE) campaigns without adding internal infrastructure or headcount. - Maintaining continuous remote access to real-time process data through the Culture Cloud Platform. - Accelerating program decisions with higher confidence than traditional, lower-throughput industry approaches. ## Complete the form to download the full PDF ## Keep exploring [See all](https://www.culturebiosciences.com/resources) [![High-Density TFF Perfusion on the Stratyx 250 Platform](https://www.culturebiosciences.com/hs-fs/hubfs/Perfusion-Featured-Image-1.png?width=500&height=500&name=Perfusion-Featured-Image-1.png) White Paper High-Density TFF Perfusion on the Stratyx 250 Platform July 20, 2026](https://www.culturebiosciences.com/resources/high-density-tff-perfusion-on-the-stratyx-250-platform) [![Real-Time Closed-Loop Optimization Delivers 43% Titer Improvement](https://www.culturebiosciences.com/hs-fs/hubfs/Ark-TB-Thumbnail.png?width=500&height=500&name=Ark-TB-Thumbnail.png) White Paper Real-Time Closed-Loop Optimization Delivers 43% Titer Improvement May 5, 2026](https://www.culturebiosciences.com/resources/real-time-closed-loop-optimization-delivers-43-titer-improvement) [![STRATYX™ Delivers Superior Viable Cell Density and Increased mAb Titer Compared with Conventional 250 mL Bioreactors in Fed-Batch CHO Culture.](https://www.culturebiosciences.com/hs-fs/hubfs/Bionova-Thumbnail.png?width=500&height=500&name=Bionova-Thumbnail.png) White Paper STRATYX™ Delivers Superior Viable Cell Density and Increased mAb Titer Compared with Conventional 250 mL Bioreactors in Fed-Batch CHO Culture. 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