--- title: A Guide for Running Statistically-Powered Clone-Screening Experiments description: Since all bioprocesses have an inherent level of variability, replicates of each clone should be run in every experiment. image: https://www.culturebiosciences.com/hubfs/Imported_Blog_Media/659b514b5f7a4947e7012e1c_Image-2-1.png --- [Skip to main content](https://www.culturebiosciences.com/resources/a-guide-for-running-statistically-powered-clone-screening-experiments#main-content) [![Culture Biosciences](https://www.culturebiosciences.com/hubfs/2026_Culture%20Biosciences/Logos/Culture%20Logo%20black.svg) ![Culture Biosciences](https://www.culturebiosciences.com/hubfs/2026_Culture%20Biosciences/Logos/Culture%20Logo%20white.svg) ![Culture Biosciences](https://www.culturebiosciences.com/hubfs/2026_Culture%20Biosciences/Logos/Culture%20Logo%20black.svg)](https://www.culturebiosciences.com) - Show submenu for Products Products - [Console Software](https://www.culturebiosciences.com/console) - [Stratyx Bioreactor](https://www.culturebiosciences.com/stratyx) - [Services](https://www.culturebiosciences.com/nexxys) - Show submenu for Resources Resources - [White Papers](https://www.culturebiosciences.com/resources/tag/white-paper) - [Case Studies](https://www.culturebiosciences.com/resources/tag/case-study) - [Blog Posts](https://www.culturebiosciences.com/resources/tag/blog-post) - [Announcements](https://www.culturebiosciences.com/resources/tag/announcement) - [Webinars](https://www.culturebiosciences.com/resources/tag/webinar) - [Videos](https://www.culturebiosciences.com/resources/tag/video) - [View All](https://www.culturebiosciences.com/resources) - [About](https://www.culturebiosciences.com/about) Open main navigation Close main navigation - Show submenu for Products Products - Products - [Console Software](https://www.culturebiosciences.com/console) - [Stratyx Bioreactor](https://www.culturebiosciences.com/stratyx) - [Services](https://www.culturebiosciences.com/nexxys) - Show submenu for Resources Resources - Resources - [White Papers](https://www.culturebiosciences.com/resources/tag/white-paper) - [Case Studies](https://www.culturebiosciences.com/resources/tag/case-study) - [Blog Posts](https://www.culturebiosciences.com/resources/tag/blog-post) - [Announcements](https://www.culturebiosciences.com/resources/tag/announcement) - [Webinars](https://www.culturebiosciences.com/resources/tag/webinar) - [Videos](https://www.culturebiosciences.com/resources/tag/video) - [View All](https://www.culturebiosciences.com/resources) - [About](https://www.culturebiosciences.com/about) - [Login](https://console.culturebiosciences.com/login) [Contact](https://www.culturebiosciences.com/contact) [Login](https://console.culturebiosciences.com/login) [Contact](https://www.culturebiosciences.com/contact) White Paper December 3, 2024 # A Guide for Running Statistically-Powered Clone-Screening Experiments ![A Guide for Running Statistically-Powered Clone-Screening Experiments](https://www.culturebiosciences.com/hs-fs/hubfs/Imported_Blog_Media/659b514b5f7a4947e7012e1c_Image-2-1.png?width=860&height=745&name=659b514b5f7a4947e7012e1c_Image-2-1.png) The primary goal of clone screening in bioreactors is to identify clones with improvements in key performance indicators (KPIs) such as titer, rate and yield over the course of a bioprocess. Since all bioprocesses have an inherent level of variability, replicates of each clone should be run in every experiment. Limited bioreactor capacity is often a primary driver of how replicates are structured rather than the desired replicate count driving bioreactor usage. In this white paper, we describe how conducting a power analysis can determine the correct sample size for a statistically powered clone screening experiment. ## Complete the form to download the full PDF ## Keep exploring [See all](https://www.culturebiosciences.com/resources) [![High-Density TFF Perfusion on the Stratyx 250 Platform](https://www.culturebiosciences.com/hs-fs/hubfs/Perfusion-Featured-Image-1.png?width=500&height=500&name=Perfusion-Featured-Image-1.png) White Paper High-Density TFF Perfusion on the Stratyx 250 Platform July 20, 2026](https://www.culturebiosciences.com/resources/high-density-tff-perfusion-on-the-stratyx-250-platform) [![Real-Time Closed-Loop Optimization Delivers 43% Titer Improvement](https://www.culturebiosciences.com/hs-fs/hubfs/Ark-TB-Thumbnail.png?width=500&height=500&name=Ark-TB-Thumbnail.png) White Paper Real-Time Closed-Loop Optimization Delivers 43% Titer Improvement May 5, 2026](https://www.culturebiosciences.com/resources/real-time-closed-loop-optimization-delivers-43-titer-improvement) [![STRATYX™ Delivers Superior Viable Cell Density and Increased mAb Titer Compared with Conventional 250 mL Bioreactors in Fed-Batch CHO Culture.](https://www.culturebiosciences.com/hs-fs/hubfs/Bionova-Thumbnail.png?width=500&height=500&name=Bionova-Thumbnail.png) White Paper STRATYX™ Delivers Superior Viable Cell Density and Increased mAb Titer Compared with Conventional 250 mL Bioreactors in Fed-Batch CHO Culture. 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