How Cell Line Screening Works at Culture
Culture’s bioreactor capacity allows for screening larger numbers of cell lines. This is important as one of the most reasonable ways to reach an adequate starting point for developing a viable manufacturing process is to screen many initial cell lines for desirable characteristics such as acceptable growth rate and high product titer and quality. Culture’s capacity enables screening of a sufficient number of cell lines with sufficient replication and controls to be in a strong position for reaching manufacturability requirements in future process development. Additionally, with sufficient capacity, this work can be performed rapidly, enabling cell line screening to be completed within allocated timelines.
Culture provides rich data sets with each experiment in real time. These include online and offline measurements that can give a detailed assessment of differences between cell lines based on growth rates, product titer, and cell line viability in order to make informed decisions around the entire performance profile of a cell line, beyond simple endpoint metrics.
For more on cell line screening, including key challenges to keep in mind and best practices: